Ion Channel Dynamics

Ion channel models are the building blocks of computational neuron models. Their biological fidelity is therefore crucial for the interpretation of simulations.

Ion channels in the brain are specialized proteins that are embedded in the cell membranes of neurons. They act as gatekeepers, regulating the flow of specific ions across the membrane in response to various signals and stimuli. Ion channels are crucial for generating and controlling electrical signals in neurons.

There are different types of ion channels in the brain, each with specific properties and functions. Some of the most important types include voltage-gated ion channels, ligand-gated ion channels, and leak channels. Voltage-gated ion channels open or close in response to changes in the electrical potential across the membrane. Ligand-gated ion channels open or close when specific molecules, such as neurotransmitters, bind to them. Leak channels allow a small, continuous flow of ions across the membrane, contributing to the resting membrane potential.

Modeling the dynamics of ion channels in the brain involves capturing their behavior and interactions using mathematical models and computer simulations.

Base Classes

IonChannel

Base class for ion channels.

Calcium Channels

CalciumChannel	Base class for Calcium ion channels.
ICaN_IS2008	The calcium-activated non-selective cation channel model proposed by (Inoue & Strowbridge, 2008) [2]_.
ICaT_HM1992	The low-threshold T-type calcium current model proposed by (Huguenard & McCormick, 1992) [1]_.
ICaT_HP1992	The low-threshold T-type calcium current model for thalamic reticular nucleus proposed by (Huguenard & Prince, 1992) [1]_.
ICaHT_HM1992	The high-threshold T-type calcium current model proposed by (Huguenard & McCormick, 1992) [1]_.
ICaHT_Re1993	The high-threshold T-type calcium current model proposed by (Reuveni, et al., 1993) [1]_.
ICaL_IS2008	The L-type calcium channel model proposed by (Inoue & Strowbridge, 2008) [1]_.

Potassium Channels

PotassiumChannel	Base class for sodium channel dynamics.
IKDR_Ba2002v2	The delayed rectifier potassium channel current.
IK_TM1991v2	The potassium channel described by (Traub and Miles, 1991) [1]_.
IK_HH1952v2	The potassium channel described by Hodgkin–Huxley model [1]_.
IKA1_HM1992v2	The rapidly inactivating Potassium channel (IA1) model proposed by (Huguenard & McCormick, 1992) [2]_.
IKA2_HM1992v2	The rapidly inactivating Potassium channel (IA2) model proposed by (Huguenard & McCormick, 1992) [2]_.
IKK2A_HM1992v2	The slowly inactivating Potassium channel (IK2a) model proposed by (Huguenard & McCormick, 1992) [2]_.
IKK2B_HM1992v2	The slowly inactivating Potassium channel (IK2b) model proposed by (Huguenard & McCormick, 1992) [2]_.
IKNI_Ya1989v2	A slow non-inactivating K+ current described by Yamada et al. (1989) [1]_.
IK_Leak	The potassium leak channel current.
IKDR_Ba2002	The delayed rectifier potassium channel current.
IK_TM1991	The potassium channel described by (Traub and Miles, 1991) [1]_.
IK_HH1952	The potassium channel described by Hodgkin–Huxley model [1]_.
IKA1_HM1992	The rapidly inactivating Potassium channel (IA1) model proposed by (Huguenard & McCormick, 1992) [2]_.
IKA2_HM1992	The rapidly inactivating Potassium channel (IA2) model proposed by (Huguenard & McCormick, 1992) [2]_.
IKK2A_HM1992	The slowly inactivating Potassium channel (IK2a) model proposed by (Huguenard & McCormick, 1992) [2]_.
IKK2B_HM1992	The slowly inactivating Potassium channel (IK2b) model proposed by (Huguenard & McCormick, 1992) [2]_.
IKNI_Ya1989	A slow non-inactivating K+ current described by Yamada et al. (1989) [1]_.
IKL	The potassium leak channel current.

Sodium Channels

SodiumChannel	Base class for sodium channel dynamics.
INa_Ba2002	The sodium current model.
INa_TM1991	The sodium current model described by (Traub and Miles, 1991) [1]_.
INa_HH1952	The sodium current model described by Hodgkin–Huxley model [1]_.
INa_Ba2002v2	The sodium current model.
INa_TM1991v2	The sodium current model described by (Traub and Miles, 1991) [1]_.
INa_HH1952v2	The sodium current model described by Hodgkin–Huxley model [1]_.

Other Channels

Ih_HM1992	The hyperpolarization-activated cation current model propsoed by (Huguenard & McCormick, 1992) [1]_.
Ih_De1996	The hyperpolarization-activated cation current model propsoed by (Destexhe, et al., 1996) [1]_.
IAHP_De1994v2	The calcium-dependent potassium current model proposed by (Destexhe, et al., 1994) [1]_.
IAHP_De1994	The calcium-dependent potassium current model proposed by (Destexhe, et al., 1994) [1]_.
LeakyChannel	Base class for leaky channel dynamics.
IL	The leakage channel current.